Sridhar Hannenhalli is a professor in the Department of Cell Biology and Molecular Genetics and holds joint appointments in the Center for Bioinformatics and Computational Biology (CBCB) and UMIACS. He also holds an affiliate position in the university's Department of Computer Science and the Department of Genetics at the University of Pennsylvania.
Hannenhalli served as the interim director of CBCB in 2013. He has previously held research positions at GlaxoSmithKline, Celera Genomics, and as assistant and then associate professor in the Department of Genetics at the University of Pennsylvania.
Hannenhalli's current research focuses on comparative genomics, transcriptional regulation, and evolution.
He has served on program committee for numerous bioinformatics conferences and chaired Workshop on Algorithms in Bioinformatics (WABI) and Research in Computational Molecular Biology (RECOMB) conferences. Hannenhalli has also served on several national and international grant review panels and as academic editor for PLOS ONE and BMC Genomics. He has co-authored more than 75 papers in computer science and bioinformatics.
Hannenhalli received his doctorate in computer science from Pennsylvania State University in 1996, where he developed combinatorial algorithms for genome rearrangement problems.
2011. Accelerated evolution of 3'avian FOXE1 genes, and thyroid and feather specific expression of chicken FoxE1. BMC Evolutionary Biology. 11(1):302-302.
2011. Regulation of Lung Endoderm Progenitor Cell Behavior by miR302/367. DevelopmentDevelopment. 138(7):1235-1245.
2011. Epigenomic and RNA structural correlates of polyadenylation. RNA Biology. 8(3):529-537.
2011. Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and FailureClinical Perspective. Circulation: Cardiovascular GeneticsCirc Cardiovasc Genet. 4(1):26-35.
2011. Transcriptional Regulation Via TF-Modifying Enzymes: An Integrative Model-Based Analysis. Nucleic Acids ResearchNucl. Acids Res.. 39(12):e78-e78-e78-e78.
2011. Genome-Wide Survey of Natural Selection on Functional, Structural, and Network Properties of Polymorphic Sites in Saccharomyces Paradoxus. Molecular Biology and EvolutionMol Biol Evol. 28(9):2615-2627.
2010. Mimosa: Mixture model of co-expression to detect modulators of regulatory interaction. Algorithms for Molecular Biology. 5(1):4-4.
2010. Genetic and Physiological Activation of Osmosensitive Gene Expression Mimics Transcriptional Signatures of Pathogen Infection in C. elegans. PLoS ONEPLoS ONE. 5(2):e9010-e9010.
2010. Correlated Changes Between Regulatory Cis Elements and Condition-Specific Expression in Paralogous Gene Families. Nucleic Acids ResearchNucl. Acids Res.. 38(3):738-749.
2010. Young Proteins Experience More Variable Selection Pressures Than Old Proteins. Genome ResearchGenome Res.. 20(11):1574-1581.
2010. Hopx and Hdac2 Interact to Modulate Gata4 Acetylation and Embryonic Cardiac Myocyte Proliferation. Developmental Cell. 19(3):450-459.
2010. Regulating the Regulators: Modulators of Transcription Factor Activity. Computational Biology of Transcription Factor BindingComputational Biology of Transcription Factor Binding. 674:297-312.
2009. Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in nondiabetic Caucasians. Clinical Endocrinology. 70(5):698-705.
2009. The evolution of Fox genes and their role in development and disease. Nature reviews. GeneticsNat Rev Genet. 10(4):233-240.
2009. Mimosa: mixture model of co-expression to detect modulators of regulatory interaction. Proceedings of the 9th international conference on Algorithms in bioinformatics. :133-144.
2009. Gene Profiling of Human Adipose Tissue During Evoked Inflammation In Vivo. DiabetesDiabetes. 58(10):2211-2219.
2009. Motifs and cis-regulatory modules mediating the expression of genes co-expressed in presynaptic neurons. Genome Biology. 10(7):R72-R72.
2009. PTM-Switchboard--a database of posttranslational modifications of transcription factors, the mediating enzymes and target genes. Nucleic Acids ResearchNucleic Acids Research. 37(Database):D66-D71-D66-D71.
2009. CTCF binding site classes exhibit distinct evolutionary, genomic, epigenomic and transcriptomic features. Genome Biology. 10(11):R131-R131.
2009. Evidence for Coregulation of Myocardial Gene Expression by MEF2 and NFAT in Human Heart Failure / CLINICAL PERSPECTIVE. Circulation: Cardiovascular Genetics. 2(3):212-219.
2008. Eukaryotic Transcription Factor Binding Sites—modeling and Integrative Search Methods. BioinformaticsBioinformatics. 24(11):1325-1331.
2008. Functional Diversification of Paralogous Transcription Factors via Divergence in DNA Binding Site Motif and in Expression. PLoS ONEPLoS ONE. 3(6):e2345-e2345.
2008. Computational Analysis of Constraints on Noncoding Regions, Coding Regions and Gene Expression in Relation to Plasmodium Phenotypic Diversity. PLoS ONEPLoS ONE. 3(9):e3122-e3122.
2008. Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development. Development. 135(16):2729-2738.
2008. Genome-Wide Analysis of Natural Selection on Human Cis-Elements. PLoS ONEPLoS ONE. 3(9):e3137-e3137.
2008. Guest Editors' Introduction to the Special Section on Algorithms in Bioinformatics. IEEE/ACM Transactions on Computational Biology and Bioinformatics. 5(4):482-483.
2008. Sex and Age Dimorphism of Myocardial Gene Expression in Nonischemic Human Heart Failure. Circulation: Cardiovascular Genetics. 1(2):117-125.
2008. A Tutorial of the Poisson Random Field Model in Population Genetics. Advances in Bioinformatics. 2008:1-9.
2007. GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo. Development. 134(1):189-198.
2007. Position and distance specificity are important determinants of cis-regulatory motifs in addition to evolutionary conservation. Nucleic Acids Research. 35(10):3203-3213.
2007. TREMOR—a tool for retrieving transcriptional modules by incorporating motif covariance. Nucleic Acids Research. 35(21):7360-7371.
2007. COMPUTATIONAL BIOLOGY. Nucleic acids research. 35(9-12):3163-3163.
2007. MetaProm: a neural network based meta-predictor for alternative human promoter prediction. BMC Genomics. 8(1):374-374.
2007. Eukaryotic Transcriptional Regulation: Signals, Interactions, and Modules. Computational genomics: current methods. :21-21.
2007. Genome-wide expression profiling and bioinformatics analysis of diurnally regulated genes in the mouse prefrontal cortex. Genome Biology. 8(11):R247-R247.
2007. Variola virus topoisomerase: DNA cleavage specificity and distribution of sites in Poxvirus genomes. Virology. 365(1):60-69.
2006. Identification and cross-species comparison of canine osteoarthritic gene regulatory cis-elements. Osteoarthritis and Cartilage. 14(8):830-838.
2006. An Interaction-Dependent Model for Transcription Factor Binding. Systems Biology and Regulatory GenomicsSystems Biology and Regulatory Genomics. 4023:225-234.
2006. Invited Talk: Deciphering Gene Regulatory Networks by in silico approaches. 6th International Workshop on Data Mining in Bioinformatics (BIOKDD06). :31-31.
2006. Retroviral DNA Integration: Viral and Cellular Determinants of Target-Site Selection. PLoS PathogPLoS Pathog. 2(6):e60-e60.
2006. Selection of Target Sites for Mobile DNA Integration in the Human Genome. PLoS Comput BiolPLoS Comput Biol. 2(11):e157-e157.
2006. Functional Analysis of Hes-1 in Preadipocytes. Molecular EndocrinologyMolecular Endocrinology. 20(3):698-705.
2006. A mammalian promoter model links cis elements to genetic networks. Biochemical and Biophysical Research Communications. 347(1):166-177.
2006. Patterns of sequence conservation in presynaptic neural genes. Genome Biology. 7(11):R105-R105.
2006. Transcriptional Genomics Associates FOX Transcription Factors With Human Heart Failure. Circulation. 114(12):1269-1276.
2006. Conservation Patterns in cis-Elements Reveal Compensatory Mutations. Comparative GenomicsComparative Genomics. 4205:186-199.
2006. Dense Subgraph Computation Via Stochastic Search: Application to Detect Transcriptional Modules. BioinformaticsBioinformatics. 22(14):e117-e123-e117-e123.
2006. Differential Transcriptional Response to Nonassociative and Associative Components of Classical Fear Conditioning in the Amygdala and Hippocampus. Learning & MemoryLearn. Mem.. 13(2):135-142.
2006. Recurring genomic breaks in independent lineages support genomic fragility. BMC Evolutionary Biology. 6(1):90-90.
2005. Generalizations of Markov model to characterize biological sequences. BMC Bioinformatics. 6(1):219-219.
2005. Genome-wide analysis of retroviral DNA integration. Nat Rev MicroNat Rev Micro. 3(11):848-858.
2005. Genome-Wide Analysis of Chromosomal Features Repressing Human Immunodeficiency Virus Transcription. Journal of VirologyJ. Virol.. 79(11):6610-6619.
2005. Enhanced position weight matrices using mixture models. Bioinformatics. 21(Suppl 1):i204-i212-i204-i212.
2004. A Note on Efficient Computation of Haplotypes via Perfect Phylogeny. Journal of Computational Biology. 11(5):858-866.
2003. Transcriptional regulation of protein complexes and biological pathways. Mammalian Genome. 14(9):611-619.
2002. Identification of transcription factor binding sites in the human genome sequence. Mammalian Genome. 13(9):510-514.
2002. Predicting Transcription Factor Synergism. Nucleic Acids ResearchNucl. Acids Res.. 30(19):4278-4284.
2002. 1.375-Approximation Algorithm for Sorting by Reversals. Algorithms — ESA 2002Algorithms — ESA 2002. 2461:401-408.
2001. Enrichment of Regulatory Signals in Conserved Non-Coding Genomic Sequence. BioinformaticsBioinformatics. 17(10):871-877.
2001. Analysis and prediction of protein functional sub-types from protein sequence alignments. EP20000203764(EP1096411)
2001. Promoter prediction in the human genome. Bioinformatics. 17(Suppl 1):S90-S96-S90-S96.
2000. Analysis and prediction of functional sub-types from protein sequence alignments. Journal of Molecular Biology. 303(1):61-76.
2000. Ligand-Receptor Pairing Via Tree Comparison. Journal of Computational Biology. 7(1-2):59-70.
1999. Bacterial Start Site Prediction. Nucleic Acids ResearchNucl. Acids Res.. 27(17):3577-3582.
1999. Transforming cabbage into turnip: polynomial algorithm for sorting signed permutations by reversals. J. ACM. 46(1):1-27.
1997. Local Rules for Protein Folding on a Triangular Lattice and Generalized Hydrophobicity in the HP Model. Journal of Computational Biology. 4(3):275-296.